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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
MCM2
All Species:
50.3
Human Site:
S468
Identified Species:
73.78
UniProt:
P49736
Number Species:
15
Phosphosite Substitution
Charge Score:
-0.07
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P49736
NP_004517.2
904
101896
S468
V
K
M
I
T
S
L
S
K
D
Q
Q
I
G
E
Chimpanzee
Pan troglodytes
XP_001136482
895
100908
S459
V
K
M
I
T
S
L
S
K
D
Q
Q
I
G
E
Rhesus Macaque
Macaca mulatta
XP_001099580
870
97929
S468
V
K
M
I
T
S
L
S
K
D
Q
Q
I
G
E
Dog
Lupus familis
XP_541736
1001
113024
S566
V
K
M
I
T
S
L
S
K
D
Q
Q
I
G
E
Cat
Felis silvestris
Mouse
Mus musculus
P97310
904
102059
S468
V
K
M
I
T
G
L
S
K
D
Q
Q
I
G
E
Rat
Rattus norvegicus
NP_001101343
905
102125
S469
V
K
M
I
T
S
L
S
K
D
Q
Q
I
G
E
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001518428
911
102482
S475
V
K
T
I
I
S
L
S
K
D
E
Q
I
G
E
Chicken
Gallus gallus
NP_001006139
888
100332
S455
V
K
M
L
V
A
L
S
K
D
E
Q
I
G
E
Frog
Xenopus laevis
P55861
886
100243
S453
V
K
A
I
V
A
L
S
K
D
E
R
I
G
E
Zebra Danio
Brachydanio rerio
NP_775364
880
98286
S447
V
K
A
I
V
A
L
S
K
D
E
R
I
G
E
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
P49735
887
100396
S453
I
A
T
I
Q
K
L
S
K
D
P
R
I
V
E
Honey Bee
Apis mellifera
XP_395109
1005
114136
S572
V
S
S
I
I
G
L
S
K
D
H
Q
I
T
D
Nematode Worm
Caenorhab. elegans
Q21902
759
84917
L389
P
G
T
A
K
S
Q
L
L
K
F
V
E
Q
V
Sea Urchin
Strong. purpuratus
XP_001177558
884
100012
S453
V
K
A
L
V
A
L
S
R
D
E
R
I
G
E
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Q43704
768
85163
R398
G
A
M
V
L
A
D
R
G
V
V
C
I
D
E
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
P29469
868
98761
S488
E
R
E
F
R
K
I
S
R
D
R
G
I
I
D
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99
95.8
87.4
N.A.
95.5
96
N.A.
93.1
88.2
86.7
80.1
N.A.
63.9
58.4
26.7
73.4
Protein Similarity:
100
99
96.1
89.1
N.A.
97.7
98.3
N.A.
95.7
93.8
93
87.6
N.A.
79.3
73.5
43.2
86.5
P-Site Identity:
100
100
100
100
N.A.
93.3
100
N.A.
80
73.3
66.6
66.6
N.A.
46.6
53.3
6.6
53.3
P-Site Similarity:
100
100
100
100
N.A.
93.3
100
N.A.
86.6
93.3
86.6
86.6
N.A.
60
60
6.6
86.6
Percent
Protein Identity:
N.A.
30.3
N.A.
N.A.
41.9
N.A.
Protein Similarity:
N.A.
48.8
N.A.
N.A.
58.9
N.A.
P-Site Identity:
N.A.
20
N.A.
N.A.
20
N.A.
P-Site Similarity:
N.A.
33.3
N.A.
N.A.
53.3
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
13
19
7
0
32
0
0
0
0
0
0
0
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
7
0
0
0
% C
% Asp:
0
0
0
0
0
0
7
0
0
88
0
0
0
7
13
% D
% Glu:
7
0
7
0
0
0
0
0
0
0
32
0
7
0
82
% E
% Phe:
0
0
0
7
0
0
0
0
0
0
7
0
0
0
0
% F
% Gly:
7
7
0
0
0
13
0
0
7
0
0
7
0
69
0
% G
% His:
0
0
0
0
0
0
0
0
0
0
7
0
0
0
0
% H
% Ile:
7
0
0
69
13
0
7
0
0
0
0
0
94
7
0
% I
% Lys:
0
69
0
0
7
13
0
0
75
7
0
0
0
0
0
% K
% Leu:
0
0
0
13
7
0
82
7
7
0
0
0
0
0
0
% L
% Met:
0
0
50
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% N
% Pro:
7
0
0
0
0
0
0
0
0
0
7
0
0
0
0
% P
% Gln:
0
0
0
0
7
0
7
0
0
0
38
57
0
7
0
% Q
% Arg:
0
7
0
0
7
0
0
7
13
0
7
25
0
0
0
% R
% Ser:
0
7
7
0
0
44
0
88
0
0
0
0
0
0
0
% S
% Thr:
0
0
19
0
38
0
0
0
0
0
0
0
0
7
0
% T
% Val:
75
0
0
7
25
0
0
0
0
7
7
7
0
7
7
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _